Recombinant Mouse Serpin F2/Alpha-2-Antiplasmin Protein(C-6His)
Activity
NA
Fusion tag
C-6His
Accession
Q61247
Mol Mass
53.2 kDa
AP Mol Mass
70-85 kDa
Expressed Host
Human Cells
Sequence
Val28-Lys491
Group
recombinants
Latin name
Mus musculus
Source
Recombinants or rec. proteins
Purity
＞95% as determined by reducing SDS-PAGE.
Stability and Storage
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
Synonym
Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2; Serpinf2
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,20% glycerol,1mM DTT,pH 8.0.
Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Description
The Recombinant Mouse Serpin F2/Alpha-2-Antiplasmin Protein(C-6His) is a α- or alpha protein sometimes glycoprotein present in blood.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Background
Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. Serpin F2 is major expressed on liver and kidney. Some other tissues such as muscle, intestine, central nervous system, and placenta also express Serpin F2 mRNA at a moderate level indicated that it is a key regulator of plasmin-mediated proteolysis in these tissues.