Thrombin heavy chain Antibody

Thrombin heavy chain Antibody

Size

0.1ml

Catalog no.

bs-1914R

Price

263 EUR

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Modification(s)

None

Gene ID number

2147

French translation

anticorps

Concentration

1ug per 1ul

Conjugation

Unconjugated

Cross reactivity

Human, Mouse, Rat

Category

Primary Antibodies

Modification site(s)

Unmodified antibody

Clonality

Polyclonal antibody

Clone number

Polyclonal antibody

Target Antigen

Thrombin heavy chain

Tested Applications

WB, IHC-P, IF(IHC-P)

Also known as

Thrombin heavy chain PAb

Purification method

This antibody was purified via Protein A.

Long name

Thrombin heavy chain Primary Polyclonal Antibody

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Specificity

This is a highly specific antibody against Thrombin heavy chain.

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Thrombin heavy chain

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names

coagulation factor II; prothrombin; F2; Cf-2; Cf2; FII; F 2; coagulation factor II thrombin; Coagulation factor II; Coagulation factor II precursor; F2; Factor II; Factor-II; Prothrombin; prothrombin B-chain; PT; serine protease; THRB; THRB_HUMAN; Thrombin; Thrombin heavy chain.

Background of the target antigen

Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.