Antithrombin (Native Protein)
Available target modification
No
Active form?
Yes
Protein subtype
N/A
Gene number
462
Protein purity
>95%
Protein type
Native
Molecular weight
65 kDa
Package form
liquid
UniProt number
P01008
Tag
untagged
Abbreviation
SERPINC1
Product Subtype
full length
Expression system
Human Blood
Storage condition
Store at -70°C
PubMed citations
See the data sheet
Shipping conditions
cool packs or dry ice
Tested applications
inhibitor of proteases
Warnings
For Research Use only.
Full name
serpin family C member 1
Other desciption
Purified from human serum.
Purification
Mentioned in the data sheet
Other names
Serpin Family C Member 1, SERPINC1
Technical datasheet
Contact us to receive the datasheet
Protein family
Inhibitor of serine proteases, Member of Serpin Family
Contents
20 mM sodium phospahte buffer pH7.4; 250 mM NaCl without BSA and Azide, free of heparin
Research area interests
Diseases associated with SERPINC1 include Thrombophilia Due To Antithrombin Iii Deficiency and Disseminated Intravascular Coagulation. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade).
Protein description
Antithrombin is the most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Peptide sequence
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK